oa Current Allergy & Clinical Immunology - Reference range for specific IgG antibodies to in the South African adult population : original research

Volume 25, Issue 4
  • ISSN : 1609-3607



Patients with aspergillosis and allergic bronchopulmonary aspergillosis (ABPA) usually present with high levels of specific IgG antibodies to . There is currently no reference range for IgG antibodies in healthy individuals in South Africa. The aim of this study was to develop a reference range in South African adults. Sera were collected from healthy blood donors who had no history of hypersensitivity to . Specific IgG against was determined using the ImmunoCAP system (Phadia, Uppsala, Sweden (now Thermo Fisher Scientific)). The distribution for specific IgG antibodies to did not have a Gaussian distribution. The log-transformed data showed excellent agreement with normality. The reference range of the log-transformed data was delimited by the 2.5th centile (mean less 1.96 standard deviations) and the 97.5th centile (mean plus 1.96 standard deviations). The (antilogged) 2.5th centile [with 90% confidence intervals] was 2.79 [2.27-3.43] mgA/l. Similarly the 97.5th centile was 66.45 [54.01-81.77] mgA/l. Thus the reference range for specific IgG antibodies to is 2.79 mgA/l to 66.45 mgA/l.

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