oa Current Allergy & Clinical Immunology - A clinical approach to drug-induced liver injury : review article

Volume 28, Issue 4
  • ISSN : 1609-3607



Drug-Induced Liver Injury (DILI) may cause substantial harm to patients and places a considerable burden on the healthcare system. DILI can be classified as a non-idiosyncratic (unpredictable). The focus of this review is on Idiosyncratic DILI. An update on the epidemiology of DILI will be presented. An overview of current knowledge of DILI risk factors pathogenesis, classification and clinical presentation will be given. An approach to DILI diagnosis and management using DILI due to tuberculosis (TB) treatment, which is a common severe adverse drug reaction in South African patients, as a practical example, will be outlined.

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