oa Current Allergy & Clinical Immunology - Transient hypogammaglobulinaemia of infancy : primary immune deficiency

Volume 29 Number 4
  • ISSN : 1609-3607



Transient hypogammaglobulinemia of infancy (THI) diagnosed either asymptomatically, with recurrent respiratory symptoms or atopic symptoms, is one of the most common primary humoral immunodeficiencies. It is characterised by a delay in the child's own IgG production, while normal IgG levels are usually reached by the age of four years. The diagnosis of THI needs to be established by the exclusion of other primary or secondary causes and it is confirmed retrospectively. Although the prognosis is good for the majority of children, a minority may develop other primary immunodeficiencies and hence a follow up of THI is indicated.

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