oa South African Journal of Chemistry - NBS as a powerful catalyst for the synthesis of -hydroxysulphides with thiolysis of epoxides under mild reaction conditions : research article

Volume 61, Issue 1
  • ISSN : 0379-4350



-Bromosuccinimide (NBS) catalyses the ring opening of various epoxides with different thiols in CHCN at room temperature under mild reaction conditions. The corresponding -hydroxysulphides are obtained in short reaction times and in good to high yields with nearly complete regioselectivity. The catalyst was compared with previously reported catalysts and only one that we have found [B(CF)] gave the same regioselectivity, but the reaction time was much longer (4 h 5 min) and the yield was considerably lower. Zn(ClO)·6HO gave slightly lower selectivity but higher yields. The reaction time was about 12 times longer.

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