1887

oa South African Journal of Chemistry - Synthesis and antioxidant activity of 3,3'-diselanediylbis (N,N-disubstituted indolizine-1-carboxamide) and derivatives : research article

Volume 61, Issue 1
  • ISSN : 0379-4350

 

Abstract

A series of novel diselenides 5a-e were synthesized from α-haloketones, α-picoline alkenes and various secondary amines under a dry nitrogen atmosphere. The structures of these compounds were established by means of their spectral data and they were screened for scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH). The results of this research showed that two of these compounds (5e and 5d) exhibited reasonable antioxidant activity. The intermediate, methyl 5-methylindolizine-1-carboxylate was prepared by condensation of methyl acrylate with 1-(carboxymethyl)-2-methylpyridinium halide, which was prepared from α-picoline and chloroacetic acid by using the Tschischibabin reaction.

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/content/chem/61/1/EJC24445
2008-01-01
2016-12-10

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