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oa South African Journal of Chemistry - Expedient access to an N-phenylpyrrolidin-2-yl heterocycle a base-induced intramolecular -Michael reaction : research article

Volume 64, Issue 1
  • ISSN : 0379-4350

 

Abstract

Ethyl 2-(1-phenylpiperidin-2-yl) acetate was formed in a spontaneous cyclization from (E)-ethyl 7-oxohept-2-enoate whereas ethyl [1-(2-bromophenyl)-2-pyrrolidinyl] acetate could be synthesized in good overall yield when employing a stoichiometric amount of base to facilitate the intramolecular -Michael reaction.

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/content/chem/64/1/EJC24534
2011-01-01
2016-12-10

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