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oa South African Journal of Chemistry - Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against : research article

Volume 66, Issue 1
  • ISSN : 0379-4350

 

Abstract

Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The biological activity of four of the compounds on the chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 µM as the lowest inhibitory concentration.

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/content/chem/66/1/EJC140139
2013-01-01
2016-12-11

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