oa South African Journal of Chemistry - Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum : research article
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 µM as the lowest inhibitory concentration.
Article metrics loading...