1887

n International SportMed Journal - The gene His472Gln polymorphism in Polish endurance athletes : original research article

Volume 14, Issue 1
  • ISSN : 1528-3356
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Abstract

Vascular endothelial growth factor (VEGF), which acts via receptor , is a major growth polypeptide for regulating skeletal muscle angiogenesis.


Original research concerned the genetic background of physical performance.
The aim of the study was to analyse the possible importance of the His472Gln polymorphism within the gene in endurance athletes and sedentary individuals, in order to reveal the possible relationships between genotype and physical performance.
In this study, the His472Gln polymorphism (rs1870377), derived from the gene, was studied in 176 male Polish endurance athletes of a nationally competitive standard and 161 unrelated volunteers for controls. Genotyping was carried out by PCR-RFLP. Significance was assessed by Chi square (X2) analysis.
The results revealed that the frequency of the Gln/Gln genotype (21.02% vs.10.56%; P = 0.014) and 472Gln allele (41.19% vs. 29.50%; P = 0.001) was significantly higher in the endurance-orientated athletes compared to sedentary controls.
In conclusion, our results suggest that the gene may be taken into consideration as a genetic marker in endurance-oriented athletes. However, this conclusion should be interpreted with great caution and be supported with more experimental studies on the polymorphisms in elite athletes.

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/content/ismj/14/1/EJC133391
2013-03-01
2016-12-11

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