oa Journal of Applied Science in Southern Africa - The physiological basis of species variations in the oral bioavailability and disposition of drugs

Volume 8, Issue 2
  • ISSN : 1019-7788



Even though mammalian species differ in physical characteristics and behaviour, they possess the same body systems that perform generally similar physiological functions. There are, however, species-related physiological adaptations that account for the uniqueness of each species. Since most adaptations are of a quantitative nature, a trend or pattern may be discernible. Whenever the pattern can be descriptionbed by a mathematical equation, it becomes possible to make some predictions. The reliability of predictions involving interspecies extrapolation depends upon knowledge of the physiological similarities of and differences between the species of interest.

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