1887

n African Journal of Laboratory Medicine - Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis - brief report

Volume 8 Number 1
  • ISSN : 2225-2002
  • E-ISSN: 2225-2010
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Abstract

South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.

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/content/journal/10520/EJC-141aaa8ea5
2019-02-22
2019-07-18

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