n Medical Technology SA - Assessment of organ dysfunction and laboratory parameters in chronic Nyaope users - research

Volume 32 Number 2
  • ISSN : 1011-5528


Nyaope is a novel psychoactive mixture of drugs unique to South Africa’s townships. A mixture of caffeine, paracetamol, opiates, sedatives, psychoactive drugs as well as antibiotics and antiretroviral drugs were identified using Time of Flight Mass Spectrometry. The Nyaope users frequently complained of severe chest and abdominal pain, excessive drowsiness, vomiting and diarrhoea with progressive weight loss. However, the effect of Nyaope on various body systems has not been verified. The purpose of this study was to investigate the status of liver, kidney, endocrine function, and haematological parameters in chronic Nyaope users. Ninety eight users participated for laboratory analyses of liver, kidney, thyroid and gonadal functions, blood counts and immunophenotyping. From these, 86.7% of users showed abnormalities in the laboratory tests performed, and 10.2% to 31.6% with possible specific organ dysfunctions. In conclusion, Nyaope users were found to have abnormal laboratory parameters that may be suggestive of organ dysfunctions, occult infections, and possible bone marrow suppression and would require further investigations.

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