n South African Gastroenterology Review - A case of severe vitamin B12 deficiency secondary to Helicobacter pylori gastritis - case report

Volume 17 Number 2
  • ISSN : 1812-1659


Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and is a major gastric infection worldwide. Approximately over 50% of the adult population in developed countries and 80% in developing countries are infected with this bacterium. H. pylori infection is invariably associated with gastritis, and triggers autoantibodies by a mechanism of molecular mimicry. It may play an important role in the impairment of vitamin B12 absorption leading to pernicious anaemia. This case report highlights H. pylori as a causative agent in vitamin B12 deficiency. H. pylori treatment reverse the underlying pathogenesis and corrects the vitamin B12 deficient state in selected individuals.

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