oa Southern African Journal of Critical Care - The elimination of microbial hotspots : a potential tactic in the war against healthcare-associated infections - editorial

Volume 35 Number 2
  • ISSN : 1562-8264
  • E-ISSN: 2078-676X



Healthcare-associated infections result in increased morbidity and mortality, and elevated healthcare costs. With the rise of multidrug resistance, extensive drug resistance and even pan-drug resistance in nosocomial organisms, the war against nosocomial infections has become a matter of even greater concern. Nowhere is this concern greater than in the intensive care unit (ICU), where patients are particularly vulnerable to infection, and drug-resistant organisms are common. The war against nosocomial infections needs to be fought on many fronts. Much emphasis is placed on the arms race to develop new antibiotics to fight these increasingly resistant organisms. Novel (or newly reimagined) therapies such as phage therapy, vaccination and newly discovered antimicrobial compounds are particularly likely to grab the headlines. As we head towards a potential post-antibiotic era, these approaches are brave rear-guard actions, but are likely to be losing battles.

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