oa Current Allergy & Clinical Immunology - Proactive therapy in atopic dermatitis - review article

Volume 32 Number 3
  • ISSN : 1609-3607



Atopic dermatitis is a chronic inflammatory skin condition with a relapsing nature. Typical treatment is reactive for acute lesions and visible flares. However, normal-looking non-lesional skin in atopic dermatitis has been shown to be immunobiologically dysfunctional, characterised by subclinical inflammation. Such ongoing, sub-clinical inflammation provides the rationale for the concept of ‘preventive’ or ‘proactive’ therapy of atopic dermatitis, with long-term intermittent use of anti-inflammatory agents in addition to regular moisturising. Regular, intermittent use of topical corticosteroids and calcineurin inhibitors have both been shown to reduce flare rates in moderate to severe atopic dermatitis, with a good safety profile.

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