n Journal of Minimum Intervention in Dentistry - What effect has CPP-ACP on the salivary pH? [October 26, 2018] - preliminary systematic literature searches

Volume 12 Number 6
  • ISSN : 1998-801X


Search result: No clinical trials or 2-arm (controlled) trials of any design (in-situ, in-vitro) could be found. Only one single-arm/longitudinal in-situ trial was identified. This trial used the test subjects as control group (without CPP-ACP).

Clinical outcomes: The results of this trial showed an increase of the saliva pH in 16 out of 25 subjects after 3 weeks. A change from the initial level of pH 6.6 to the final level of around pH 7.6 was observed.

State of evidence and recommendations: The current level of evidence to this topic is still weak. Do to the lack of clinical trials no information are currently available about any clinical effect of CPP-ACP on the salivary pH of patients. The current results of the identified in-situ trial are only exploratory and require further investigation.

[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of results and thus do not replace the need for a full systematic review report to the topic]

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