oa Current Allergy & Clinical Immunology - ABC of allergy

Volume 33 Number 1
  • ISSN : 1609-3607



Dr Do-a-lot discusses antibodies. She explains to her students that the antibody that tends to cause the most mischief is the one that has the lowest concentration in the blood. Immunoglobulin E (IgE), which is produced in the plasma cells of the immune system, is the ‘allergy antibody’ and it plays an essential role in Type I hypersensitivity. Clinically this type of hypersensitivity may manifest as various allergic diseases including asthma, allergic rhinitis, food allergies, urticaria, dermatitis and anaphylaxis. IgE also plays a role in immunity to parasites. IgE, which binds to receptors on immune cells, was discovered in the late nineteen sixties.

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