oa South African Journal of Chemistry - Synthesis of some 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione derivatives by a one-pot, three-component reaction - research article

Volume 70 Number 1
  • ISSN : 0379-4350



This study reports the reduction of α,β-unsaturated ketones 4a–g, formed by condensation of arylglyoxals 2a–g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones 6a–g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.

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