1887

oa Journal of Endocrinology, Metabolism and Diabetes in South Africa - Insulin resistance induced by antiretroviral drugs : current understanding of molecular mechanisms : review article

Volume 14, Issue 3
  • ISSN : 1608-9677

 

Abstract

The increase in incidence of HIV infection continues to be a major public health problem across the world, but more especially in sub-Saharan Africa. Treatment with highly active antiretroviral therapy (HAART) has improved the prognosis of patients with AIDS, but it has also increased the incidence of various metabolic disorders, in particular insulin resistance accompanied by dyslipidaemia, hyperglycaemia and lipodystrophy. This is often accompanied by frank type 2 diabetes and increased mortality from cardiovascular disease. It is important to understand the mechanistic basis for these side-effects as the incidence of these is likely to increase as the rollout of antiretroviral drugs continues.

Loading full text...

Full text loading...

Loading

Article metrics loading...

/content/m_jemdsa/14/3/EJC64208
2009-01-01
2016-12-10

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error