1887

n South African Journal of Psychiatry - CINP 2005 Regional Meeting Cape Town, 20 - 22 April 2005 : abstracts

Volume 11, Issue 1
  • ISSN : 1608-9685
USD

 

Abstract

Extracted from text ... Psychiatry: Selected abstracts ANTIPSYCHOTICS ACROSS THE SPECTRUM: AN OVERVIEW OF THEIR MECHANISMS OF ACTION Anissa Abi-Dargham (Professor of Clinical Psychiatry and Radiology at Columbia University) Imaging studies in schizophrenia have shown an association between dopaminergic hyperactivity in the mesolimbic pathway and positive symptoms, and suggested dopaminergic hypoactivity in the mesocortical pathway underlying cognitive impairment and negative symptoms. In addition, studies of dopamine glutamate interactions have shown that dopaminergic alterations in schizophrenia may be secondary to a glutamatergic dysfunction. These data support a predominant and well established role for D2 antagonism in the treatment of schizophrenia, while providing new strategies for ..

Loading full text...

Full text loading...

Loading

Article metrics loading...

/content/m_sajp/11/1/EJC66013
2005-04-01
2016-12-10

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error