oa South African Medical Journal - Penicillin in early syphilis results obtained in 365 cases

Volume 24, Issue 8
  • ISSN : 0256-9574
  • E-ISSN: 2078-5135



The results obtained in treating 365 cases of early syphilis with a treatment schedule entailing the administration of penicillin, arsenic and bismuth of a 7 1/2-8 day period, are put forward. Only a small number, 86 (23.56%) of the original 365 cases continued to attend for a 12-month period. Of this number 12 (13.95%) were treatment failures. There were no serious reactions observed in any of the patients who were all admitted to hospital for treatment. Seventy-six (20.82 %) of the original 365 cases had a complete spinal fluid examination at the sixth month after the completion of treatment. In one of these only was a doubtful reaction observed in the Wassermann tests, all other tests being normal. The schedule tested cannot be regarded as giving very satisfactory results in view of the considerable number of treatment failures in secondary syphilis. The results emphasize once more the favourable outcome in early primary syphilis compared with that obtained in later cases.

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