The significance of bee body protein is discussed in relation to the sensitivity reactions exhibited by bee sting sensitive persons. A method is descriptionbed of desensitizing bee sting sensitive persons by the intracutaneous injections of graded strengths of extract of bee body protein. Details are given of the preparation and standardization of this extract. A descriptionption is given of the preliminary skin tests necessary in determining the degree of the patient's sensitivity to bee body protein before desensitization is commenced. The difficulty of evaluating any method of bee sting desensitization is emphasized, but three cases are quoted in which effective desensitization appears to have been achieved by the method descriptionbed.