It is suggested that the planning of the management of many congenital anomalies should be against the background of the known embryology and the known or suspected foetal hazards during the first 12 weeks of pregnancy.
The aetiologic factors underlying congenital heart disease have been reviewed under the headings of chromosomal aberrations, single gene disorders and environmental conditions.
Congenital malformations are a major cause of intra-uterine foetal loss, of neonatal loss and morbidity and also of mental and physical handicap in later life.
No attempt has been made in this paper to cover the wide vista of congenital neurologic disease, and those of genetic causation have only been touched upon.
In teenstelling met die sekondere vorms wat ontstaan as gevolg van denervasie of misbruik, vertoon die primere miopatiee 'n toename van verskeie serum ensieme.