Twelve healthy male volunteers participated in an open cross-over study designed to test whether two fixed-dose combination formulations of penbutolol (40 mg) and furosemide (20 mg), an ordinary and a film-coated tablet, are bio-equivalent.
In part I of this article we report on 89 hypertensive patients who underwent 9 months of treatment with oxprenolol HCI 160 mg in a slow-release formulation plus cyclopenthiazide 0,25 mg and potassium chloride 600 mg (Trasidrex; Ciba-Geigy).
In a multicentre trial a single daily oral dose of indapamide 2,5 mg (Natrilix; Servier) was prescribed to 387 hypertensive patients by their general practitioners for a period of 12 weeks, the common protocol permitting adjuvant therapy where necessary.
The influence of prophylactic antimicrobial therapy with lincomycin and metronidazole on the vaginal carriage rates of anaerobes and the development of postoperative infection was studied in 60 women who underwent emergency surgery.
A multicentre trial involving 1350 patients evaluated by 310 practitioners throughout South Africa was conducted to determine whether overseas studies relating to the efficacy and toleration of piroxicam (Feldene; Pfizer) would be confirmed in the local environment.