1887

n South African Gastroenterology Review - Hepatitis B and C virus infection and liver function in aids patients : research

Volume 1, Issue 2
  • ISSN : 1812-1659
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Abstract

&lt;I&gt;Backround:&lt;/I&gt; Impaired liver function tests and co-infection with hepatitis viruses in AIDS patients are common in western countries. &lt;br&gt;&lt;I&gt;Objective:&lt;/I&gt; To asses liver function and prevalence of co-infection with hepatitis B and hepatitis C viruses in AIDS patients at Chris Hani Baragwanath Hospital. &lt;br&gt;&lt;I&gt;Design:&lt;/I&gt; A prospective study. &lt;br&gt;&lt;I&gt;Setting:&lt;/I&gt; Chris Hani Baragwanath Hospital, Johannesburg, South Africa. &lt;br&gt;&lt;I&gt;Patients:&lt;/I&gt; One hundred consecutive patients with AIDS admitted to Chris Hani Baragwanath Hospital. &lt;br&gt;&lt;I&gt;Results:&lt;/I&gt; There were 52 males and 48 females aged 16 to 54 years (mean + SD: 34.6 + 7.5 years). The results of laboratory test were as follows: LFTs: bilirubin 11.8 (<u>+</u>15.6)<SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;mol/L; AST: 79.6 (<u>+</u>116.6) i<SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;/L; alkaline phosphatase: 204.3 (<u>+</u>237.4) I<SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;/L; albumin: 23.9 (<u>+</u>6.2) g/Ll; CD4+ lymphocytes: 141.6 (<u>+</u>168.6) <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;L; CD8+: 666.9 (<u>+</u>618.3) <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;L; HBV - HbsAg: 6 (6%); HbsAg + eAg: 3 (3%); previous disease (AntiHBs and/or anti HBc): 35%. HCV: 1 (1%). &lt;br&gt;&lt;I&gt;Conclusion:&lt;/I&gt; Liver function tests were impaired in the majority of patients with AIDS (93%) in our setting. Evidence of previous and present HBV infection was present in 41%. This is different from what is observed in western countries (90-95%). The results also suggest that patients here acquired HBV infection while still immuno competent. HCV infection was rare.

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/content/medgas/1/2/EJC71767
2003-11-01
2016-12-09

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