n South African Gastroenterology Review - Management of acute gastric ulcer bleeding : review

Volume 10, Issue 1
  • ISSN : 1812-1659



At one time peptic ulcer disease accounted for 50-70% of acute non-variceal UGIB (Barkun et al., 2004). Approximately 80% of these ulcers stop bleeding spontaneously. Gastric ulcer is more frequently the source of UGIB (55% versus 37%); compared to duodenal ulcer (Enestvedt et al., 2008). The current practice to use proton pump inhibitors as ulcer prophylaxis and eradication of Helicobacter pylori, has led to a worldwide decrease in the incidence of bleeding from peptic ulcer. However, this seems applicable only to patients younger than 70 years of age (Lanas et al., 2005; Loperfido et al., 2009; Targownik et al., 2006). Recent population-based estimates have suggested that the incidence is about 60 per 100,000 of the population (Lassen et al., 2006), with the incidences related to the use of aspirin and non-steroidal anti-inflammatory drugs on the increase (Ohmann et al., 2005).

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