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n Obstetrics and Gynaecology Forum - Tamoxifen : a review of its mechanism of action and effects on the female genital tract : review article

Volume 14, Issue 4
  • ISSN : 1027-9148
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Abstract

Extracted from text ... REVIEW 17 Tamoxifen: a review of its mechanism of action and effects on the female genital tract The nature and mechanism of action of tamoxifen "the first SERM" Tamoxifen, a non-steroidal trimethyl-ethylene derivative has been termed the first Specific oEstrogen Receptive Modulator or SERM. An understanding of the oestrogen receptor (ER) structure and function has allowed the development of agents which selectively rather than generally deliver oestrogen agonism where required or antagonism where necessary.2, 3 Two intra-nuclear oestrogen receptors are currently recognized and there may be others.2, 4 The first oestrogen receptor described, the so-called classical oestrogen receptor ..

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/content/medog/14/4/EJC73219
2004-10-01
2016-12-10

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