n Obstetrics and Gynaecology Forum - Prevention of pre-eclampsia : calcium supplementation and other strategies : review

Volume 26, Issue 3
  • ISSN : 1029-1962


Pre-eclampsia is strikingly more common in low- than high-income countries. Understanding the mechanisms responsible for these differences may provide clues to strategies to prevent the condition. One possible factor is dietary deficiency. Calcium supplementation in the second half of pregnancy for women with low dietary calcium intake has a limited effect on the incidence of pre-eclampsia, but an important 20% reduction in its severe manifestations. The World Health Organization recommends calcium supplementation with 1.5 to 2 g calcium daily for pregnant women with low dietary calcium intake. Tentative evidence suggests that a lower dose (e.g. 500 mg daily) may be adequate. Research is ongoing to determine whether pre-and early pregnancy supplementation with calcium may reduce the incidence of pre-eclampsia more effectively. There is insufficient evidence of effectiveness at this stage to recommend other dietary supplements such as Vitamin D, anti-oxidants (Vitamin C and E), magnesium and marine oils, but further research is justified. Low dose aspirin (75mg daily) has a modest protective effect and is recommended from 12 weeks to delivery for women at high risk of pre-eclampsia.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error