1887

oa Southern African Journal of Anaesthesia and Analgesia - Comparison of dexmedetomidine versus midazolam for intranasal premedication in children posted for elective surgery : a double-blind, randomised study : research

Volume 21, Issue 6
  • ISSN : 2220-1181

 

Abstract

The aim of this study was to compare the effect of dexmedetomidine with midazolam for intranasal premedication in children posted for elective surgery. Trial design: This was a prospective, randomised, double-blinded clinical study.


60 children, 3 to 10 years of age, with American Society of Anaesthesiologists (ASA) physical status I, scheduled for elective surgery, were randomly divided into two groups, group D (dexmedetomidine) and group M (midazolam). Group D patients received intranasal dexmedetomidine 1 µg/kg and group M patients intranasal midazolam 0.2 mg/kg, approximately 30 minutes before induction of anaesthesia, in the form of a spray.
Preoperative effects on heart rate, blood pressure, sedation and anxiety including parental separation and mask acceptance were assessed.
Intranasal dexmedetomidine (1 µg/kg) premedication resulted in statistically significant but clinically unimportant lower heart rate and blood pressure at 10, 20, and 30 minutes following administration compared with intranasal midazolam (0.2 mg/kg). There were no episodes of hypotension or bradycardia. Children in group D achieved better parental separation and mask acceptance scores compared with group M.
Dexmedetomidine resulted in better parental separation and mask acceptance scores than intranasal midazolam. Thus it would seem to offer some advantage compared with midazolam.

Loading full text...

Full text loading...

Loading

Article metrics loading...

/content/medsajaa/21/6/EJC182686
2015-01-01
2016-12-09

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error