n Medical Technology SA - Effect of Low Level Laser Therapy on human skin keratinocytes : peer reviewed short review

Volume 23, Issue 2
  • ISSN : 1011-5528


Low Level Laser Therapy (LLLT) is a form of phototherapy which involves the application of low power monochromatic and coherent light to injuries and lesions. Re-epithelialisation of skin wounds begin hours after injury and depends upon the migration of keratinocytes from the margins of the wound across the wounded area before the onset of proliferation. Laser therapy leads to a complex set of physiological interactions at the cellular level that reduces acute inflammation, reduces pain and accelerates tissue healing. Compromised cells and tissue respond more readily to laser therapy than normal healthy cells. Laser therapy aims to normalize cell function and in doing so can be used to restore homeostasis. This review article focuses on the effect of LLLT on keratinocyte migration and proliferation specifically for wound healing. The review also addresses the role of laser and reactive oxygen species (ROS) in wound healing and also proposes that fibroblasts and not keratinocytes may be the preferred target for laser therapy. The results of many current studies are controversial and warrant further investigation. Despite the negative reports, there are many scientific studies that confirm the beneficial effects of laser therapy.

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