n Medical Technology SA - Case study : spurious elevation of sodium levels : peer reviewed case study

Volume 28, Issue 1
  • ISSN : 1011-5528


In hospitalized patients, plasma sodium disturbances remain common and can be associated with significant mortality and morbidity if not diagnosed and treated. A hypoproteinaemic, critically ill patient with discrepant blood gas analyzer and central laboratory analyzer sodium values presented as a case of possible spurious elevation of sodium or pseudohypernatraemia. The indirect ion selective electrode method yielded a persistently higher sodium value than the direct ion selective electrode method. A statistically significant difference between the sodium measured with the direct ISE and indirect ISE method was noted. The differences could not be explained by analytical variation alone, in most of the samples.

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