oa South African Family Practice - Cardiovascular effects and the use of nonsteroidal anti-inflammatory drugs : CPD article

Volume 56, Issue 1
  • ISSN : 2078-6190
  • E-ISSN: 2078-6204



Nonsteroidal anti-inflammatory drugs (NSAIDs) include the nonselective and the cyclo-oxygenase-2-specific inhibitors. These agents are used for pain associated with musculoskeletal conditions. The nonselective anti-inflammatory drugs are still widely used, and are also freely available as over-the-counter analgesics. However, they carry the risk of serious cardiovascular adverse effects, especially in patients who have a high, pre-existing cardiovascular risk profile. It is imperative that physicians are aware of these risk factors and choose agents that have the best benefit-to-risk profile, while taking into consideration the patient's individual risk profile.

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