oa Southern African Journal of Epidemiology and Infection - Current clinical controversies in the treatment of sepsis : review article

Volume 22, Issue 4
  • ISSN : 1015-8782
  • E-ISSN: 2220-1084



Sepsis continues to represent an unmet medical need and is a major cause of morbidity and mortality in intensive care units. Recently four major new developments have been reported, each of which appears to have a significant beneficial effect. These are : the use of low dose steroids, early goal-directed therapy, intensive insulin therapy and drotrecogin alfa (activated). Despite early enthusiasm, in each case significant concerns and reservations have emerged. Here, these issues are considered and the current status of these treatments is discussed.

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