oa SA Pharmaceutical Journal - Antihistamines - a brief review : clinical
The prevalence rates of allergic diseases such as allergic rhinitis and asthma appear to be increasing in many countries. Although several mediators are involved in the patho-physiology of allergic diseases, histamine plays a fundamental role, particularly in allergic rhinitis and urticaria. Produced and stored within the cyto-plasmic granules of mast cells and basophils, histamine is released in large quantities during the immediate phase of allergic reactions.
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