oa SA Pharmaceutical Journal - Combination therapy for hypertension : review

Volume 76, Issue 8
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Current blood pressure treatment guidelines call for a single drug to be tried first in people with Stage 1 hypertension, i.e. those with a systolic reading over 140 mmHg and a diastolic reading over 90 mmHg (but with readings of less than 160 mmHg systolic and 100 mmHG diastolic). However, because of the pathophysiological complexity underlying hypertension, many patients obtain better control of their blood pressure with a combination of antihypertensives than with monotherapy. Various studies show that low-dose drug combination in the treatment of hypertension allows for a greater reduction in blood pressure, often with fewer side effects, as well as providing reduced cardiovascular morbidity and mortality.

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