oa SA Pharmaceutical Journal - The role of COX inhibitors in various physiological systems : medifile

Volume 77, Issue 5
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



This article gives an overview of the physiology of the COX enzymes, selectivity of NSAIDs and efficacy of COX-2 selective inhibitors in comparison to nonselective ones.

Many articles focus on the cardiovascular side-effects of COX-2 inhibitors, but in this paper we describe the effects of COX inhibition in a number of other physiological systems, for example the bones and soft tissues, kidneys, lungs and the female reproductive tract. In particular we look at the gastrointestinal tract, where factors such as infection and duration of NSAID use may influence clinical outcomes.
Furthermore, we investigate the potential role of COX inhibition in the treatment of Alzheimer's disease and cancer. Lastly, we address the controversy of some COX-2 inhibitors possibly being cardioprotective and look at their safety in combination with aspirin.

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