oa SA Pharmaceutical Journal - The antidepressant properties of azure B and a synthetic analogue of methylene blue - : cum laude

Volume 81, Issue 1
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Use of methylene blue is gaining interest as a novel approach to treating Alzheimerâ??s disease and bipolar disorder. The goal of this study was to design a close structural analogue of methylene blue and to evaluate the effect of the said structural changes on monoamine oxidase (MAO) inhibition and its antidepressant properties, and to compare this to that of the known antidepressant, imipramine, as well as methylene blue and its metabolite, azure B. The aforementioned and the synthetic methylene blue analogue, ethyl-thioninium-chloride (ETC), were studied for antidepressant and locomotor effects in the forced swim test (FST), and an automated animal activity monitor, respectively.

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