oa SA Pharmaceutical Journal - Lamivudine monotherapy as a holding regimen in the era of antiretroviral treatment resistance : forum

Volume 82, Issue 9
  • ISSN : 2221-5875
  • E-ISSN: 2220-1017



Limited treatment options are available for HIV-infected paediatric patients that are virologically failing combination antiretroviral treatment (cART). This paper describes the use of lamivudine monotherapy (LM) as a holding strategy for the short-term treatment of specific multi-drug resistant paediatric patients, where a definite suppressive cART regimen is not possible. Lamivudine monotherapy should only be used under close supervision and monitoring of an expert HIV clinician.

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