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oa Wound Healing Southern Africa - The role of advanced glycation end products in the hyperinflammatory response of diabetic wounds : general review

Volume 4, Issue 1
  • ISSN : 1998-8885

 

Abstract

Chronic wounds are a frequent complication in diabetic patients and contribute significantly to morbidity and mortality. In the hyperglycaemic state, advanced glycation end products (AGEs) form, affecting collagen cross-linking, cytokine, nitric oxide and growth factor production and molecular signalling pathways. AGE receptors are upregulated and as it activates NF-kappaB, a host of inflammatory cytokines are expressed, exacerbating the self-sustaining inflammatory response seen in diabetic wounds. Therapeutic strategies include inhibiting the formation of AGEs, either directly or by inhibiting the formation of intermediates, and blocking the AGE receptor. A more complete understanding of the biology of the diabetic wound healing process is imperative in the development of successful treatment of diabetic wounds.

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/content/mp_whsa/4/1/EJC82778
2011-01-01
2016-12-10

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