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oa Wound Healing Southern Africa - Randomized controlled trial of three burns dressings for partial thickness burns in children : wound care

Volume 9, Issue 1
  • ISSN : 1998-8885

 

Abstract

This study compared the effects of three silver dressing combinations on small to medium size acute partial thickness burns in children, focusing on re-epithelialization time, pain and distress during dressing changes.


Children (0-15 years) with clean, ≤10% total body surface area (TBSA) partial thickness burns who met the inclusion criteria were included in the study. Children received either (1) Acticoat™; (2) Acticoat™ with Mepitel™; or (3) Mepilex Ag™ dressings. Measures of burn reepithelialization, pain, and distress were recorded at dressing changes every 3-5 days until full re-epithelialization occurred.
One hundred and three children were recruited with 96 children included for analysis. No infections were detected for the course of the study. When adjusted for burn depth, Acticoat™ significantly increased the expected days to full re-epithelialization by 40% (IRR = 1.40; 95% CI: 1.14-1.73, p < 0.01) and Acticoat™ with Mepitel™ significantly increased the expected days to full re-epithelialization by 33% (IRR = 1.33; 95% CI: 1.08-1.63, p - 0.01) when compared to Mepilex Ag™. Expected FLACC scores in the Mepilex Ag™ group were 32% lower at dressing removal ( = 0.01) and 37% lower at new dressing application ( = 0.04); and scores in the Acticoat™ with Mepitel™ group were 23% lower at dressing removal ( = 0.04) and 40% lower at new dressing application ( < 0.01), in comparison to the Acticoat™ group.Expected Visual Analog Scale-Pain (VAS-P) scores were 25% lower in the Mepilex Ag™ group at dressing removal ( = 0.04) and 34% lower in the Acticoat™ with Mepitel™ group ( = 0.02) at new dressing application in comparison to the Acticoat™ group. There was no significant difference between the Mepilex Ag™ and the Acticoat™ with Mepitel™ groups at all timepoints and with any pain measure.
Mepilex Ag™ is an effective silver dressing, in terms of accelerated wound epithelialization time (compared to Acticoat™ and Acticoat™ with Mepitel™) and decreased pain during dressing changes (compared to Acticoat™), for clean, <10% TBSA partial thickness burns in children.

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/content/mp_whsa/9/1/EJC190660
2016-01-01
2016-12-10

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