oa South African Journal of Science - Antiplasmodial activities of some abietane diterpenes from the leaves of five species : research letter

Volume 104, Issue 1-2
  • ISSN : 0038-2353
  • E-ISSN: 1996-7489



Seven known abietane diterpenes were isolated from five species, namely subsp. and subsp. . The seven compounds were tested for their antiplasmodial activity and for their ability to inhibit ß-haematin formation. Overall, they showed good activity (IC values ranging from 3.11 to 14.65 M), with one compound being 62% as effective as chloroquine in inhibiting ß-haematin formation. However, the cytotoxicity profile indicated a low degree of specificity towards the malaria parasite. When combined with quinine, three compounds interacted in an additive manner whereas one interacted synergistically.

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