oa Journal of the South African Veterinary Association - Endotoxaemia in racehorses following exertion

Volume 59, Issue 2
  • ISSN : 1019-9128
  • E-ISSN: 2224-9435



Endotoxins (lipopolysaccharides - LPS) and anti-endotoxin IgG antibodies were measured in racehorses before and after races of 1 000, 2 000 and 2 800 m. Results show that the mean plasma concentration of endotoxin increased significantly (p < 0,02) while the anti-LPS IgG concentration decreased significantly (p < 0,005) in all horses following the races. Pre-race and post-race anti-LPS IgG levels in racing-fit racehorses were significantly higher than in untrained horses (p<0,05). The possibility therefore exists that training-induced stress leads to leakage of LPS into the systemic circulation which results in self-immunisation against LPS. The effects of plasma LPS and anti-LPS IgG concentrations on performance of racehorses require further studies. Key words: Anti-endotoxin IgG, endotoxin, exercise, Thoroughbred

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