1887

n Journal of the South African Veterinary Association - Lack of susceptibility of to imidocarb dipropionate

Volume 69, Issue 2
  • ISSN : 1019-9128
  • E-ISSN: 2224-9435

Abstract

<I>In vitro&lt;/I&gt; antimicrobial susceptibility testing was used to compare the efficacy of imidocarb dipropionate and doxycycline on the growth of <I>Ehrlichia canis&lt;/I&gt; in DH82 cell cultures. Over a 9-day period there were no significant differences (&lt;I&gt;p&lt;/I&gt; < 0.01) in the growth of <I>E. canis&lt;/I&gt; in untreated control wells and those to which imidocarb dipropionate was added at 1.2, 2.4, 4.8 or 12 <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;g/m&lt;I&gt;&amp;#8467;&lt;/I&gt; for the 1st 3 days. Average infection rates rose from 50 to 55 % on day 0 to 100 % on day 5 or 6. Doxycycline at 1 <SPAN lang=AF style="FONT-FAMILY: Symbol; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font: Symbol"&gt;m&lt;/SPAN&gt;&lt;/SPAN&gt;g/m&lt;I&gt;&amp;#8467;&lt;/I&gt; had residual or rickettsiocidal activity against <I>E. canis&lt;/I&gt; with the average percentages of DH82 cells infected declining from 51 to 24 % while the organism was exposed to the drug (3 days) and from 21 to 2 % in the 6 days following removal of the drug from the cell culture medium.

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/content/savet/69/2/EJC99218
1998-06-01
2019-05-26

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